Neutrophil‐to‐lymphocyte ratio and platelet‐to‐lymphocyte ratio are associated with disease activity in polymyalgia rheumatica

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A disease activity score for polymyalgia rheumatica.

OBJECTIVE To develop a composite score for measurement of disease activity in polymyalgia rheumatica (PMR) and assess its internal and external validity. METHODS A PMR activity score (AS) was designed and assessed for internal and external validity in two patient cohorts: 57 international patients evaluated primarily for development of the PMR-AS at baseline, weeks 4 and 24; and for validatio...

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Serum markers associated with disease activity in giant cell arteritis and polymyalgia rheumatica.

OBJECTIVE To compare multiple serum markers for their ability to detect active disease in patients with GCA and in those with PMR. METHODS Twenty-six markers related to immune cells that may be involved in GCA and PMR were determined by ELISA and multiplex assay in the serum of 24 newly diagnosed, untreated GCA/PMR patients, 14 corticosteroid (CS)-treated GCA/PMR patients in remission and 13 ...

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Are polymyalgia rheumatica and giant cell arteritis the same disease?

OBJECTIVE To summarize the evidence about the relationship between polymyalgia rheumatica (PMR) and giant cell arteritis (GCA). METHODS Review of relevant articles from the English-language literature. RESULTS Epidemiologic studies suggest that PMR and GCA are closely related conditions affecting people over 50 years and frequently occurring in the same patient. PMR symptoms have been obser...

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Peripheral arterial disease in polymyalgia rheumatica

Patients with polymyalgia rheumatica have been shown to have an increased risk of peripheral arterial disease on longitudinal follow-up. Possible explanations for this include premature atherosclerosis related to chronic inflammation, as with other inflammatory rheumatological conditions. Alternatively, polymyalgia rheumatica can be associated with vasculitis, even in the absence of clinical gi...

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Subclinical vasculitis in polymyalgia rheumatica.

Polymyalgia rheumatica (PMR) is an inflammatory condition of the aging population characterised by pain, stiVness, and symmetrical involvement of shoulder and pelvic girdles. It has been proposed that the primary site of disease may reside outside the synovial joint, 2 but its aetiopathogenesis remains ill understood. There is good indirect evidence that vasculitis is important in the pathogene...

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ژورنال

عنوان ژورنال: Journal of Clinical Laboratory Analysis

سال: 2019

ISSN: 0887-8013,1098-2825

DOI: 10.1002/jcla.23000